
Ciprofloxacin hydrochloride
CAS No. 93107-08-5
Ciprofloxacin hydrochloride ( BAY-o 9867 | NSC 620634 )
产品货号. M16662 CAS No. 93107-08-5
一种广谱抗菌羧基氟喹啉。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
500MG | ¥332 | 有现货 |
![]() ![]() |
1G | ¥478 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Ciprofloxacin hydrochloride
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述一种广谱抗菌羧基氟喹啉。
-
产品描述A broad-spectrum antimicrobial carboxyfluoroquinoline.(In Vitro):Ciprofloxacin (Bay-09867) monohydrochloride (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.Ciprofloxacin (Bay-09867) monohydrochloride shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively.(In Vivo):Ciprofloxacin (Bay-09867) monohydrochloride (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall.Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall.
-
体外实验Ciprofloxacin (Bay-09867) monohydrochloride (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.Ciprofloxacin (Bay-09867) monohydrochloride shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively. Cell Viability Assay Cell Line:Tendon cells Concentration:5, 10, 20 and 50 μg/mL Incubation Time:24 hours Result:Decreased the cellularity of tendon cells.Cell Cycle Analysis Cell Line:Tendon cells Concentration:50 μg/mL Incubation Time:24 hours Result:Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells.Western Blot Analysis Cell Line:Tendon cells Concentration:50 μg/mL Incubation Time:0, 6, 12, 17 and 24 hours Result:Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulatedthe expression of PLK-1 protein.
-
体内实验Ciprofloxacin (Bay-09867) monohydrochloride (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall. Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall. Animal Model:BALB/c mice Dosage:30 mg/kg Administration:Intraperitoneal injection; for 24 hours Result:Reduced the lung bacterial load in murine model of pneumonic plague.Animal Model:C57BL/6J mice Dosage:100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.Animal Model:C57BL/6J mice Dosage:100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
-
同义词BAY-o 9867 | NSC 620634
-
通路Cell Cycle/DNA Damage
-
靶点DNA gyrase
-
受体DNA gyrase| Topo II| Topo IV
-
研究领域——
-
适应症——
化学信息
-
CAS Number93107-08-5
-
分子量367.8
-
分子式C17H18FN3O3·HCl
-
纯度>98% (HPLC)
-
溶解度DMSO: 10 mM
-
SMILESCl.OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Lee JK, et al. Microbiol Immunol. 2005;49(7):647-53.
产品手册




关联产品
-
Levofloxacin hydroch...
左氧氟沙星水合物是一种抗菌剂,可抑制细菌 DNA 旋转酶的超螺旋活性,从而阻止 DNA 复制。
-
Norfloxacin
诺氟沙星(Norxacin)是一种广谱抗生素,对革兰氏阳性菌和革兰氏阴性菌均具有活性。
-
Balofloxacin
Balofloxacin 是一种喹诺酮类抗生素,通过干扰 DNA 旋转酶来抑制细菌 DNA 的合成。