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Ciprofloxacin hydrochloride

CAS No. 93107-08-5

Ciprofloxacin hydrochloride ( BAY-o 9867 | NSC 620634 )

产品货号. M16662 CAS No. 93107-08-5

一种广谱抗菌羧基氟喹啉。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG ¥332 有现货
1G ¥478 有现货

生物学信息

  • 产品名称
    Ciprofloxacin hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    一种广谱抗菌羧基氟喹啉。
  • 产品描述
    A broad-spectrum antimicrobial carboxyfluoroquinoline.(In Vitro):Ciprofloxacin (Bay-09867) monohydrochloride (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.Ciprofloxacin (Bay-09867) monohydrochloride shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively.(In Vivo):Ciprofloxacin (Bay-09867) monohydrochloride (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall.Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall.
  • 体外实验
    Ciprofloxacin (Bay-09867) monohydrochloride (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.Ciprofloxacin (Bay-09867) monohydrochloride shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively. Cell Viability Assay Cell Line:Tendon cells Concentration:5, 10, 20 and 50 μg/mL Incubation Time:24 hours Result:Decreased the cellularity of tendon cells.Cell Cycle Analysis Cell Line:Tendon cells Concentration:50 μg/mL Incubation Time:24 hours Result:Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells.Western Blot Analysis Cell Line:Tendon cells Concentration:50 μg/mL Incubation Time:0, 6, 12, 17 and 24 hours Result:Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulatedthe expression of PLK-1 protein.
  • 体内实验
    Ciprofloxacin (Bay-09867) monohydrochloride (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall. Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall. Animal Model:BALB/c mice Dosage:30 mg/kg Administration:Intraperitoneal injection; for 24 hours Result:Reduced the lung bacterial load in murine model of pneumonic plague.Animal Model:C57BL/6J mice Dosage:100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.Animal Model:C57BL/6J mice Dosage:100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
  • 同义词
    BAY-o 9867 | NSC 620634
  • 通路
    Cell Cycle/DNA Damage
  • 靶点
    DNA gyrase
  • 受体
    DNA gyrase| Topo II| Topo IV
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    93107-08-5
  • 分子量
    367.8
  • 分子式
    C17H18FN3O3·HCl
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 10 mM
  • SMILES
    Cl.OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Lee JK, et al. Microbiol Immunol. 2005;49(7):647-53.
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